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3
37
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72921 |
Reversin 121
|
||
Reversin 121为P-糖蛋白(P-glycoprotein) 抑制剂,能增加MDR1的ATP酶活性,可逆转P-糖蛋白介导的多药耐药性,适用于癌症研究。 | |||
T76976 | Tixagevimab | ||
Tixagevimab (AZD8895)为人源单克隆抗体,针对SARS-CoV-2的受体结合结构域(RBD)具有靶向性。该抗体通过结合RBD及S糖蛋白外域,进而阻断S糖蛋白与受体的结合,展示出对SARS-CoV-2的中和活性。 | |||
T80575 |
Simaravibart
MAD-0004J08 |
SARS-CoV | Microbiology/Virology |
Simaravibart (MAD-0004J08) 是一种IgG1κ 抗体,靶向SARS-CoV-2刺突(S)糖蛋白的受体结合域。 | |||
T80581 |
Plutavimab
COVI-AMG,STI-2020 |
SARS-CoV | Microbiology/Virology |
Plutavimab为针对SARS-CoV-2 Spike (S) 糖蛋白受体结合域 (RBD) 的人源化IgG1-κ型单克隆抗体。 | |||
T78659 |
Crexavibart
BMS-986413,C-144-LS |
SARS-CoV | Microbiology/Virology |
Crexavibart (BMS-986413; C-144-LS)是一种IgG1λ2抗体,专门针对SARS-CoV-2刺突(S)糖蛋白的受体结合域。 | |||
T76923 | Beludavimab | ||
Beludavimab (BMS 4182137; VIR 7832) 是一种针对 SARS-CoV-2刺突糖蛋白的单克隆抗体。Beludavimab 与重组刺突蛋白受体结合域 (S-RBD) 结合,EC50值为 14.9 ng/mL,Kd 为 0.21 nM。 | |||
T74426 | Ogalvibart | ||
Ogalvibart (C-135-LS)为人源化抗SARS-CoV-2单克隆抗体(IgG1型),能够与SARS-CoV-2的S蛋白RBD紧密结合。当与C144LS以1:1比例联合使用时,Ogalvibart显示出优异的预防活性,能有效预防恒河猴疾病模型中COVID-19的发展。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0012 |
coniferyl ferulate
|
P-gp; GST | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Coniferyl ferulate 是从川芎中提取的一种天然产物,是强效的谷胱甘肽 S-转移酶抑制剂,强抑制人胎盘型谷胱甘肽 S-转移酶,IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。 | |||
T2799 |
(20S)-Protopanaxadiol
20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇 |
Apoptosis; Reactive Oxygen Species; P-gp | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物,是一种凋亡诱导剂,抑制Akt 活性并诱导多种肿瘤细胞凋亡。 | |||
TN6872 |
Trypsin
|
Protease-activated Receptor | GPCR/G Protein |
Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶,可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性,可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合,可激活 PAR2 和 PAR4,促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00441 |
SARS-COV-2 Spike S Trimer Protein (His & Avi), Biotinylated
Spike glycoprotein,S glycopro... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the acce... | |||
TMPK-00435 |
SARS-COV-2 Spike S Trimer Protein (D614G, His & Avi)
S protein,Spike glycoprotein,COVI... |
SARS-CoV-2 | HEK293 Cells |
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Recently, that D614G was been found more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin. | |||
TMPK-00438 |
SARS-COV-2 Spike S Trimer Protein (His & Avi)
COVID-19,S protein,S glycoprotein... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the accession number i... | |||
TMPK-00442 |
SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated
S glycoprotein,COVID-19,S protein... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 13... | |||
TMPH-00262 |
Bovine coronavirus (strain OK-0514) Spike glycoprotein (Yeast, His)
E2,Spike glycoprotein,Peplomer protein, |
BCoV | P. pastoris (Yeast) |
Bovine coronavirus (strain OK-0514) Spike glycoprotein (Yeast, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 36.5 kDa and the accession number is Q9QAQ8. | |||
TMPH-00258 |
Bovine coronavirus (strain Quebec) Spike glycoprotein (His)
S,E2,Spike glycoprotein,S |
BCoV | P. pastoris (Yeast) |
Bovine coronavirus (strain Quebec) Spike glycoprotein (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 36.8 kDa and the accession number is P25193. | |||
TMPH-00261 |
Bovine coronavirus (strain vaccine) Spike glycoprotein (His)
Spike glycoprotein,E2,S glyco... |
BCoV | E. coli |
Bovine coronavirus (strain vaccine) Spike glycoprotein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 24.6 kDa and the accession number is P25194. | |||
TMPH-00260 |
Bovine coronavirus (strain 98TXSF-110-LUN) Spike glycoprotein (His)
Peplomer protein,S,E2,S glycoprotein |
BCoV | HEK293 Cells |
Bovine coronavirus (strain 98TXSF-110-LUN) Spike glycoprotein (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 37.3 kDa and the accession number is Q8V436. | |||
TMPH-00257 |
Bovine coronavirus (strain LY-138) Spike glycoprotein (His)
S,Peplomer protein,E2,S glycoprotein |
BCoV | P. pastoris (Yeast) |
Bovine coronavirus (strain LY-138) Spike glycoprotein (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 36.6 kDa and the accession number is P25192. | |||
TMPK-00434 |
SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 51.7 kDa and the accession ... | |||
TMPK-00911 |
SARS Spike RBD Protein (His & Avi)
S protein RBD,Spike protein RBD,S... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number is P59594. | |||
TMPH-00263 |
Bovine coronavirus (strain OK-0514) Spike glycoprotein (His)
Peplomer protein,S,S glycoprotein... |
BCoV | HEK293 Cells |
Bovine coronavirus (strain OK-0514) Spike glycoprotein (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9QAQ8. | |||
TMPK-00439 |
SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession nu... | |||
TMPK-00912 |
SARS Spike RBD Protein (His & Avi), Biotinylated
S glycoprotein RBD,S protein RBD,... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number... | |||
TMPH-00259 |
Bovine coronavirus (strain Mebus) Spike glycoprotein (His)
S,Peplomer protein,Spike glycoprotein<... |
BCoV | E. coli |
Bovine coronavirus (strain Mebus) Spike glycoprotein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 24.7 kDa and the accession number is P15777. | |||
TMPK-00437 |
SARS-COV-2 Spike RBD Protein (His & Avi)
S glycoprotein RBD,Spike protein ... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is A0A6G7... | |||
TMPH-00195 |
Bat coronavirus HKU3 Spike glycoprotein (His)
Peplomer protein,S glycoprotein,S... |
BtCoV | Baculovirus Insect Cells |
Bat coronavirus HKU3 Spike glycoprotein (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 24.3 kDa and the accession number is Q3LZX1. | |||
TMPH-00196 |
Bat coronavirus HKU3 Spike glycoprotein (E. coli, His)
E2,Peplomer protein,Spike glycoprotein, |
BtCoV | E. coli |
Bat coronavirus HKU3 Spike glycoprotein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.9 kDa and the accession number is Q3LZX1. | |||
TMPH-00193 |
Bat coronavirus 133/2005 Spike glycoprotein (His & Myc)
Spike glycoprotein,S glycopro... |
BtCoV | E. coli |
Bat coronavirus 133/2005 Spike glycoprotein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.6 kDa and the accession number is Q0Q4F2. | |||
TMPY-02569 |
MAG Protein, Human, Recombinant (His)
SIGLEC4A,myelin associated gl... |
Human | HEK293 Cells |
MAG Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P20916. | |||
TMPH-00197 |
Bat coronavirus HKU9 Spike glycoprotein (His)
Peplomer protein,Spike glycoprotein,E2, |
BtCoV | E. coli |
Bat coronavirus HKU9 Spike glycoprotein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.6 kDa and the accession number is A3EXG6. | |||
TMPY-03147 |
MAG Protein, Human, Recombinant (hFc)
S-MAG,SIGLEC4A,myelin ass |
Human | HEK293 Cells |
MAG Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.7 kDa and the accession number is P20916-1. | |||
TMPK-00432 |
SARS-COV-2 Spike S1 Protein (hFc & Avi)
Spike protein S1,S glycoprote... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A6... | |||
TMPK-00443 |
SARS-COV-2 (Omicron B.1.1.529) Spike S1 Protein (His & Avi), Biotinylated
Spike,S1 protein,S glycoprote... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.94 kD... | |||
TMPK-00440 |
SARS-COV-2 Spike S1 Protein (His & Avi), Biotinylated
S1 protein,S glycoprotein S |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.9 kDa and the accession n... | |||
TMPK-00909 |
SARS Spike S1 Protein (hFc & Avi), Biotinylated
Spike protein S1,S glycoprote... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number... | |||
TMPK-00908 |
SARS Spike S1 Protein (hFc & Avi)
Spike protein S1,S1 protein,S... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number is P59594. | |||
TMPK-00913 |
SARS Spike S1 Protein (His & Avi), Biotinylated
Spike protein S1,S glycoprote... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number ... | |||
TMPK-00444 |
SARS-COV-2 Spike S1 NTD Protein (His & Flag)
S1 protein NTD,Spike glycoprotein... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 NTD Protein (His & Flag) is expressed in HEK293 mammalian cells with C-His-Flag tag. The predicted molecular weight is 35 kDa and the accession number is A... | |||
TMPK-00436 |
SARS-COV-2 Spike S1 Protein (D614G, His & Avi)
Spike,S1 protein,Spike protein |
SARS-CoV-2 | HEK293 Cells |
The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct. | |||
TMPK-00433 |
SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated
S1 protein,Spike,S1 protein,S... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession ... | |||
TMPK-00910 |
SARS Spike S1 Protein (His & Avi)
S1 protein,S glycoprotein S |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number is P59594. | |||
TMPY-02204 |
LBP Protein, Human, Recombinant (His)
BPIFD2,lipopolysaccharide binding protein |
Human | HEK293 Cells |
Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and purified aggregates of extracted endotoxin and catalyzes the delivery of endotoxin to the membrane ( mCD14, GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to end... | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
|
Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
TMPY-06885 |
SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)
|
||
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPY-02769 |
RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonucleas |
Human | Baculovirus Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... | |||
TMPJ-00352 |
CD98 Protein, Human, Recombinant (mFc)
Lymphocyte activation antigen 4F2 large subunit,4F2... |
Human | HEK293 Cells |
CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis,... |